The Era of the Middle Ages: 476 to 1453.
Two Events called 'the Great Schism': 1054, the Great Schism separating Eastern and Western Christianity - Eastern headquartered in Constantinople and Western centred in Rome: 1378-1417 during which time the Western Church (basically the Church of Rome) had more than one person claiming to be the rightful Pope (heir of St. Peter).
It may be likely the second Great Schism is the one you are more interested in. If this is an assignment question, you may want to demonstrate to your marker/instructor the question is vague. The First Great schism is more often seen as 'the' Great Schism rather than the second. An argument can be made neither of these Schisms (splits or separations) in Church formation or polity really had any effect on the ending of the Middle Ages in Europe.
First Great Schism - 1054:
Two trends; Eastern Christendom was holding its own and even reclaiming territory previously ceded to the Macedonian Emperors. At this same time Western Christendom was losing ground to the Arabs. The Greek Church was growing both in wealth and status while the Western Church appeared to the Easterners as being controlled by barbarians. Hence, there were issues mostly not about beliefs (theology) which were causing the two entities to become separated. The Eastern Church criticized the Church of Rome over the celibacy of priests and for using unleavened bread in the Eucharist. The Eastern Church was more engaged in the arts than was the Church of Rome at this time. It was likely the Eastern Church had more money to spend on religious paintings and icons.
Second Great Schism (1378-1417):
When the Papal seat moved to Avignon, in France, the Italians were suspicious of all the dealings the Pope(s) from there. All these Popes were French by ethnicity and were viewed as favouring, politically, the rulers of France at this time. We see the 'marriage' of Church and State becoming an institution in its own right in France. Even though the moving of the papacy from Rome to Avignon was justified by turbulence and anarchy in Rome, in no real terms was Avignon a perfectly safe haven. This Great Schism came close to dividing the Church of Rome and may well have been one of the contributing factors leading up to the Reformation (closing out the Renaissance era) under the leadership of such theologians as Martin Luther, and John Calvin. There were even arguments bandied about at this time suggesting any pope ruling the Church from the 'wrong' geographical location must be the 'anti-Christ'. At the top of this response I gave the years of the Middle Ages as 476 to 1453. Not all scholars agree to this specific set of dates. Some scholars seem not to differentiate between the Renaissance and the Reformation eras. You will need to work out these details for the answer anticipated by any marker by reading what your assigned texts have to say about such matters.
Machiavelli, during the Renaissance era created a Discourse he entitled, "The Importance with Which Religion Must be Regarded and How Italy, Lacking It, Thanks to the Church of Rome, has been Ruined". While some see Machiavelli as an 'enlightened' thinker of his day, that is not my opinion. I would place his mindset back to the day of the second Great Schism more or less. It would be interesting to include something about this Discourse of Machiavelli in any paper you may be composing for an assignment. You would want to make certain your instructor/marker would know where you stand in terms of agreeing with Machiavelli. Again, much of what I have included here, you need to contrast and compare with source materials required and recommended for your course of study.
All except one of the sources I have used in this response recognize only the First Great Schism as 'the' Great Schism. As is always the case I urge you compare the source material cited in this response with that cited by others. Generally the Second Great Schism has been given the title of 'The Babylonian Exile' by such scholars as Martin Luther. This takes Church historians back to the day when the People of Israel were held captive in Babylon prior to the birth of Christ.
I and many other scholars view the Renaissance and then the Reformation coming on the heels of the Middle Ages - Medieval Europe.